Publisher's Synopsis
This publication looks at the current status of research aimed at understanding the role of some crucial DNA binding proteins, particularly transcriptional factors, in the senescence of normal diploid cells. It features timely reviews, perceptive analyses, and current research focusing on transcription factors whose binding activities have been clearly demonstrated to be age-dependent in normal cells. Life scientists in broad areas such as biochemistry, molecular biology, cancer biology, and gerontology should read this publication, in particular those interested in cell cycle, cellular aging, cell transformation, and gene regulation.
