Publisher's Synopsis
This volume represents a summary of reports on studies using the Senescence Accelerated Mouse, as presented at the 2nd International Conference on Senescence: The SAM Model, held from 21-23 July in Sapporo, Japan.
Work on the SAM began in 1968 in the Department of Pathology, Chart Disease Research Institute (currently Field of Regeneration Control Institute for Frontier Medical Sciences) of Kyoto University. Since 1982, experiments on the SAM have been carried out in over 300 laboratories in Japan and other countries.
Many emerging aspects of the SAM model were successfully dealt with at the first conference, which was held in 1994 in Kyoto. Dramatic progress in research on the SAM model has been made since. The focus of this conference was on findings obtained by using the SAM model and pertinent information was provided by investigators working on the SAM model together with comments for those who are about to embark on SAM-related investigations.
Many excellent papers included in this issue offer new insights into the significance of the SAM as an animal model of aging.
