Publisher's Synopsis
This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1908 edition. Excerpt: ...as Saccharomyces neoformans. In most cases, the tumours thus produced were nothing but inflammatory pseudo-plasms. But, with cultures of a microbe of this kind, isolated from a fermenting infusion of lemon-skin, he claims to have produced, by inoculation, malignant epithelial neoplasms (cancers) in dogs. When these cultures were injected into the peritoneal cavity, nodular formations at first resulted; from these fresh cultures were made, and after the microbe had thus been passed through several dogs, it was found to have acquired increased virulence. Of thirty dogs inoculated with cultures thus produced, in two Sanfelice claims to have caused true epithelial cancer. In the case of a bitch inoculated in the posterior mammary region, there was considerable tumefaction at the seat of inoculation one month afterwards. The animal then became cachectic, and died ten months after inoculation. Besides the mammary tumour, post-mortem examination revealed enlargements of the adjacent inguinal and abdominal lymph-glands. Histologically examined, all of these tumours showed 1 British Medical Journal, 1892, vol. ii., p. 1356. 1 Cent. f. Bakt., etc., 1895, Bd. xvii., S. 113 and 625; Bd. xviii., S. 521; Bd. xxiii., SS. 155 and 276; and Bd. xxi., 1902, S. 254. Also series of articles in Zeits. f. Hygiene und Inleclions-krankheiten, 1895, Bd. xxi., SS. 32 and 394; Bd. xxii., 1896, S. 171; Bd. xxvi., S. 298; Bd. xxix., 1898, S. 463. the structure of glandular cancer. Numerous "parasites " were present in them, but no cultures could be obtained. The latter defect is unfortunate, as the possibility of the animal having been previously affected with mammary cancer, to which bitches are exceedingly prone, thus cannot be excluded. A similar defect...
