Publisher's Synopsis
Excerpt from The Journal of Experimental Medicine, Vol. 34: December 1, 1921; Studies on the Treatment of Human Trypanosomiasis With Tryparsamide (the Sodium Salt of N-Phenylglycineamide-P-Arsonic Acid)
It is Obvious that any extended application of a new remedy for administration in human beings must be preceded by a careful study of its action in relatively few patients irrespective of the scope of the initial investigations in the laboratory. In a problem such as the therapy Oi human trypanosomiasis as just indicated, it is of the utmost importance to ascertain such fundamental facts as the initial speed of therapeutic activity Of various sized single doses, as measured by the length of time required to clear the superficial lymph glands and blood of trypanosomes and the permanency of this effect; the action Of the drug, if any, in the advanced stages Of the disease as indicated by examination Of the Spinal ?uid and the mental and nervous response of the patient; the general physical reaction of the patient as shown by weight Observations, blood counts, etc.; and finally, the determina tion of any untoward observable effects. On the basis of a series of such facts obtained in a certain number Of patients, a rational system Of therapeutic procedure can then be logically attempted.
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