Regulation of Cellular Signal Transduction Pathways by Desensitization and Amplication

Molecular Pharmacology of Cell Regulation Series Editor: Miles D. Houslay This important series provides topical, in–depth and authoritative reviews on all aspects of the molecular mechanisms of cell regulatory processes. It attempts to unravel the molecular structures, properties and functions of systems which provide putative targets for the next generation of drugs. It will, therefore, be of major interest to biochemists, pharmacologists, molecular pathologists,endocrinologists, cell biologists and research clinicians working on the fundamental description of how cells regulate their own and each other’s activity, on the development of novel therapeutic agents and on analyses of pathological changes and genetic lesions. Volume 3 Regulation of Cellular Signal Transduction Pathways by Desensitization and Amplification Edited by David R. Sibley National Institutes of Health, Bethesda, Maryland, USA and Miles D. Houslay Institute of Biochemistry, University of Glasgow, UK Amplification and desensitization are well recognized phenomena in signal transduction systems and descriptions of such phenomena are essential in order to gain insight into the coordinated functioning of cells in normal, pathological and transformed states. Written by international experts, this book will appeal to biochemists, pharmacologists and other experimental biologists interested in cellular signalling systems.