Publisher's Synopsis
Excerpt from Proceedings of the Society for Experimental Biology and Medicine, 1916-1917, Vol. 14
Rabbits were inoculated with material from the brains after death of seven cases of parenchymatous syphilis, and we have succeeded in obtaining strains in four cases.
Two of these strains were lost after the second generation, but of the two remaining, we have been able to continue one to the seventh and the other to the ninth generation. Although these strains have not passed through so many generations, lesions have occurred in a sufficient number of rabbits of each generation to afford some interesting deductions. In reference to the percentage of takes, there has been a slight variation in the two strains studied. While one of the strains has produced lesions in eighty to ninety per cent. Of the rabbits inoculated, the other has shown a ?uctuation between seventy and one hundred per cent. The incubation periods have likewise exhibited some irregularity. SO far they have varied from sixteen to sixty seven days, but have averaged from nineteen to thirty-one days. Neither of the strains have shown any distinctive features in regards to the incubation time. The character of the lesions has constituted a factor Of considerable significance, in that both hard nodules and large diffuse processes have been obtained.
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