Publisher's Synopsis
Genetic engineering is the direct manipulation of an organism's genome using biotechnology. It could be used to change physical appearance, metabolism, and even improve physical capabilities and mental faculties such as memory and intelligence. The text Pragmatism and Human Genetic Engineering presents overviews and pro and con viewpoints on human genes and regulation of genetic engineering. First chapter focuses on genetic engineering and biotechnology of growth hormones. The aim of second chapter is to investigate the feasibility of a plasmid-based strategy for genetic modification of human (h)MSC with enhanced green fluorescent protein (EGFP) and/or neurotrophin (NT)3. Human leukocyte antigen (HLA) engineering of human pluripotent stem cells has been discussed in third chapter. In fourth chapter, we describe the construction of HCMV BAC mutants using a homologous recombination system. In fifth chapter, we present genetically engineered mouse models for human lung cancer. Sixth chapter proposes a new algorithm for diagnosing of Parkinson's disease based on voice analysis. In seventh chapter, we review the major challenges in biomarker validation processes, including pre-analytical (sample-related), analytical, and post-analytical (data-related) aspects of assay development. Last chapter discusses how enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases.
