Publisher's Synopsis
Offered here is a detailed examination of in vitro and in vivo models and methodologies used in the study of inflammation. The book details the means by which several mediators of inflammatory responses such as arachidonic acid metabolites, platelet activating factor and interleukin-1 are analyzed and quantitated in the laboratory. The text also elaborates several in vivo models of acute inflammation and analgesia that are suitable for drug discovery and that enable the study of changes in cell infiltration, blood flow and vascular permeability, in response to therapeutic intervention. This work will be of interest to researchers, postdoctoral fellows, graduate students, and laboratory personnel in pharmacology, toxicology, physiology, rheumatology, and immunology.
