Publisher's Synopsis
Examines the pathogenesis of human pulmonary tuberculosis in all of its stages, with a primary focus on the rabbit model. Reviews the interplay of delayed-type hypersensitivity and cell-mediated immunity, clearly showing how both are needed to control the growth of the tubercle bacillus and how antibodies contribute to these cellular immune responses. Covers the histochemistry of macrophage activation; the roles of various cytokines; the effects of glucocorticoids, estrogens, thyroid hormones, and irradiation on the disease; and principles of immunization against tuberculosis, including vaccine development. Focuses on areas of future research that could contribute to the knowledge, treatment, and control of this disease. Serves as a resource for clinicians, public health investigators, and laboratory researchers in tuberculosis and immunology.
