Publisher's Synopsis
Whilst the basic principles underlying the bioenergetics of mitochondria have been understood for some time, it has only recently become clear that defects in the mitochondrial genome, such as major deletions and point mutations, cause a number of human diseases, chiefly mitochondrial myopathies and encephalopathies, and Leber's hereditary optic neuopathy. This book aims to bridge the gap between basic research and clinical practice by bringing together the genetic and bioenergetics aspects of mitochondrial metabolism.;Research workers, clinicians and postgraduate students interested in bioenergetics, reperfusion damage, mitochondrial myopathies and neurodegenerative disorders should find this book of interest.