Publisher's Synopsis
The International Agency for Research on Cancer, in collaboration with the International Programme on Chemical Safety of the World Health Organization and the Commission of the European Communities, convened a meeting in Lyon in December 1985 to review the conduct and use of long- and short-term assays for the detection of chemical carcinogens, taking into account the progress made in the understanding of the process of carcinogenesis and the scientific basis of the various endpoints used in these assays. The meeting was attended by about 60 experts in the fields of carcinogenesis, mutagenesis and cell biology, who prepared a series of reports on bioassays for carcinogenicity in animals and short-term tests to predict carcinogenicity. In the report on long-term carcinogenicity assays, particular attention was paid to (a) the role of pharacokinetic data in the design and evaluation of such assays, (b) early preneoplastic lesions in carcinogenesis, and (c) the possibility for discriminating the relative contribution that carcinogens may make to the various stages of the process of carcinogensis.;Readership: oncology, experimentalists.
