Herbal Treatment of Major Depression: Scientific Basis and Practical Use

Herbal Treatment of Major Depression: Scientific Basis and Practical Use - Clinical Pharmacognosy Series

Paperback (30 Jun 2021)

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Publisher's Synopsis

This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K, Akt, mTOR, GSK3, BDNF, and other intracellular pathways. New theories of the pathophysiology underlying major depression, such as oxidative damage, inflammation, stress and insulin resistance are then explored.

Key Features:



  • Focuses on oxidative damage, inflammation, and metabolic syndrome.


  • Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications.


  • These facts lead to discussion of herbs that can be used to treat major depression, as well as consideration of the scientific basis for how these herbs act.


  • The antidepressant properties of 66 herbs are discussed, along with dosing and safety information.

Book information

ISBN: 9781032087153
Publisher: CRC Press
Imprint: CRC Press
Pub date:
DEWEY: 616.852706
DEWEY edition: 23
Language: English
Number of pages: 420
Weight: 678g
Height: 154mm
Width: 235mm
Spine width: 27mm