Publisher's Synopsis
This book is about the role of heat shock proteins (hsps) in candidiasis, aspergillosis and dimorphic fungal infections. It examines fundamental issues, such as their role in pathogenicity and induction of an immune response, and clinical applications such as their value as diagnostic markers and targets for antifungal therapy. Topics covered include the possibility of immunotherapy for systemic candidiasis in the form of human recombinant antibodies to candidal hsp90, a putative role of hsp90 in the Candida albicans steroid-responsive receptor complex, parallels between the hsp90 of Aspergillus fumigatus and the water mould Achlya ambisexualis, and the role of hsp in adapting dimorphic fungi from a saprobic to a parasitic state.
