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Diagnosis of Hirschsprung's Disease

Diagnosis of Hirschsprung's Disease

Paperback (10 Feb 2025)

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Publisher's Synopsis

Hirschsprung's disease (HD) is a rare congenital disorder defined by the absence of ganglion cells (GCs) in a segment of the digestive tract. Its diagnosis in Tunisia relies solely on histopathological study with hemathein-eosin. Currently, several studies are being carried out on biomarkers of MH, notably on the anti-calretinin antibody. The aim of our work was to evaluate the diagnostic performance of the anti-calretinin antibody in the context of suspected HD. This was a retrospective study including 69 patients with MH. An immunohistochemical study with anti-calretinin antibody was performed. In MPA biopsies, CGs were labeled in 2 biopsies, while interstitial nerve fibers were labeled in 3 biopsies. The sensitivity, specificity, positive predictive value and negative predictive value of the anti-calretinin antibody were 93%, 100%, 100% and 70% respectively.The use of an immunohistochemical study with anti-calretinin antibody in the absence of GC is a reasonable alternative in view of the serious therapeutic implications of HD.

Book information

ISBN: 9786208624392
Publisher: KS Omniscriptum Publishing
Imprint: Our Knowledge Publishing
Pub date:
Language: English
Number of pages: 68
Weight: -1g
Height: 229mm
Width: 152mm
Spine width: 4mm