Publisher's Synopsis
This book is a unique compendium of the latest information on cytokine knockouts. Each chapter-written by the leading scientists who created or studied each knockout-illuminates the physiological consequences of deficiency in a particular cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed.
