Publisher's Synopsis
Accurate transmission of genetic information in cells is ensured by DNA repair, delays in replication until repairs are complete, and by cell death. Work in yeast and subsequently in mammalian cells has shown that monitoring the cell cycle generates signals which halt it at specific "checkpoints". Failures in these processes can release uncontolled cell division. This volume examines the mechanisms of checkpoint control, the cellular activities they influence, and their importance in understanding the fundamentals of the neoplastic process.
