Central and Peripheral Mechanisms in Pituitary Disease - Hypo CCS S.

This is the sixth volume in a series of HypoCSS publications dedicated to detailed, in-depth analysis of pituitary pathophysiology and disease states. The theme of the 2002 book deals with the basis of loss of pituitary function and the development of pituitary tumours that over-produce specific hormones. In addition, a second theme relates to the molecular and cellular actions of growth hormones (GH) and IGF-I.;The earlier chapters provide multiple new insights into the molecular pathogenesis of the disorders that result in excessive, or loss of, normal GH secretion and, in the latter case, the effect of G-protein mutations on pituitary tumour formation and the role of negative hormonal feedback in controlling pituitary tumour formation are also presented in great detail.;The later chapters discuss the regulation of endocrine IGF-I by GH action in the liver and the differentation between endocrine versus autocrine/paracrine actions of IGF-I in the periphery, along with the clinical models of GH resistance syndrome in humans and the importance of gene polymorphisms in lowering serum IGF-I.;The international HypoCSS advisory broad is a group of experts in the field of pituitary diseases, chaired by Professor Steven Lamberts. The group is concerned with the surveillance of long-term safety of growth hormone therapy in adults and all aspects of pituitary function and disease.