Publisher's Synopsis
This guide provides an understanding of the molecular and cellular biological approaches to cancer and also a detailed overview of advances being made in clinical research on cancer treatment. It begins with a thorough fundamental and objective review of oncogene identification, activation, products, and functions. Topics on the biology of tumor cells are included, ranging from growth factors and receptors to tumor progression, metastasis, and resistance to drug therapy. In addition, the text examines antibodies and other biological response modifiers as preventive, diagnostic, and therapeutic agents, and provides an analysis of human tumor lines.;Specific topics covered include: relationships of tumors and differentiation; phenotypic, karyotypic, and genetic heterogeneity of tumors; how genetic events unmask recessive alleles to cause malignancy; chromosomal abnormalities; how patterns of oncogene expression permit classification of histopathologically similar tumors; the biology of lung, breast, and neuroectodermal human solid tumors.
