Publisher's Synopsis
Excerpt from Analysis of Path-Based Approaches to Genomic Physical Mapping
It is known in random graph theory (1) that, in certain randomstructures, paths of bounded length suffice to connect essentially all pairs of points. This phenomenon has recently gained popular attention through John Guare's award-winning play, Six Degrees of Separation, in which it is asserted that any two people in the world can be connected through a path of at most six acquaintances.
Within an integrated genomic physical map, this same phenomenon could occur even if the majority of the clone overlaps are valid. A small rate of falsely declared clone overlaps can lead to spurious coverage of large regions of the genome.
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