Publisher's Synopsis
Since ancient time, skin is used by humans to apply different types of substances for the intention of therapeutic effect. In 20th century, skin is used for longer duration of delivery of different dosage forms. Mostly drugs that are available in market are used to be administered by the oral route, but oral route suffers different limitations. Transdermal Patch is an adhesive system that is used after placing at skin surface to reach systemic circulation. Repaglinide belong to meglitinide class and lowers the blood sugar level. It stimulate the release of insulin from pancreas. One hour is it half life that is very short. Furthermore it has low bioavailability (56%) because of the first pass effect. It is given 3 to 4 times per day in the dose of 0.5-4 mg. Due to all these issues related with Repaglinide, was used in current study to develop and evaluate matrix type transdermal patches. This study concludes that by the means of patches Repaglinide can be administered efficiently.
