Publisher's Synopsis
Excerpt from The Physiologic Chemistry of Uric Acid
Nucleohiston may be extracted from finely divided thymus-glands with water, and precipitated from its aqueous solution with acetic acid, avoiding an excess in which the recently precipitated body is soluble. The moist substance is soluble in dilute acids and alkalies and in dilute neutral salt-solution. It is worthy of note that nucleohiston gives the Millon and xantho proteic reactions, and the biuret-coloration faintly on standing. It contains a little more than 3% of phos phorus. Novy has found that subcutaneous injection of gram or more in rabbits causes elevation of tem perature of from 1� to C., preceded by a short period of subnormal temperature. Nucleohiston, as well as its nucleinic-acid constituent, precipitates diph theria-toxin, but, as Novy states, this undoubtedly is a mechanical effect; the toxin being carried down with the precipitated proteids. However, nucleohiston does have some destructive action on diphtheria-toxin after the mixture has stood for some time in vitro, although separate injections do not protect animals. (novy.)
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